The .com version of a domain name is aimed at international rather than specifically US companies or commercial organisations. A .co.uk domain name suggests a UK-based operation although there is no practical restriction on who can buy a .co.uk domain. So how do you decide which to register or whether to register both?
Cost is no big issue as .co.uk domains cost just £9.99 each and with the .com version at £19.99 it hardly breaks the bank. So for under £30 you can have both versions.
.com can suggest more substance and more prestige than a simple .co.uk. There is a suspicion that some of the top US and international search engines and internet directories are more sympathetic to including .com domains than others and may also rank them more highly than other types of domain. On the other hand some specifically UK search engines and directories do prefer .co.uk names for inclusion in their lists so a .com may not get you the best possible ranking in the UK.
It depend from where your targeted audience will come on website, if your business is located on United State than .us is good and if you located on United Kingdom than .co.uk is best for your website. If you want to check your desired .us and .co.uk domain name availability on G-talk than add email@example.com on G-talk id.
Both us and uk domain extensions are good only, based on your requirements and in which area you have plan to improve your business, then go through it. In my opinion .com is the best while compare to all.
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